Sadness. Grief. Depression.  Any sense fo loss that causes you to become in a state of emotional or mental turmoil is detrimental to you as a person.  These emotional states all begin in the arena that does not exist in the physical (i.e., your mind and spirit) but results in affecting your physical wellbeing. Everyone has a point in their life that they experienced disappointment, grief, depression, and it seems that all the cares of the world become a burden.  if not handle properly these issues can become open wounds in the heart and settle deep in the soul. It is from my experience that suppressing those issues does not help, but learning how to process those issues is the beginning of healing and growing.  With Jesus all things are possible, even resetting our emotions, our focus, and our walk in life.  The key is to understand that these emotions belong to you, and you do not belong to them.